Chao CC, Gutiérrez-Vázquez C, Rothhammer V, Mayo L, Wheeler MA, Tjon EC,Zandee SEJ, Blain M, de Lima KA, Takenaka MC, Avila-Pacheco J, Hewson P, Liu L, Sanmarco LM, Borucki DM, Lipof GZ, Trauger SA, Clish CB, Antel JP, Prat A, Quintana FJ. Metabolic Control of Astrocyte Pathogenic Activity via cPLA2-MAVS.Cell. 2019 . [link to PubMed]
Publications
Metabolic Control of Astrocyte Pathogenic Activity via cPLA2-MAVS.
Control of tumor-associated macrophages and T cells in glioblastoma via AHR and CD39.
Takenaka MC, Gabriely G, Rothhammer V, Mascanfroni ID, Wheeler MA, Chao CC, Gutiérrez-Vázquez C, Kenison J, Tjon EC, Barroso A, Vandeventer T, de Lima KA, Rothweiler S, Mayo L, Ghannam S, Zandee S, Healy L, Sherr D, Farez MF, Pratt A, Antel J, Reardon DA, Zhang H, Robson SC, Getz G, Weiner HL, Quintana FJ.Nat Neurosci. 2019 May;22(5):729-740. [link to PubMed]
Prophylactic TLR9 stimulation reduces brain metastasis through microglia activation.
Benbenishty A, Gadrich M, Cottarelli A, Lubart A, Kain D, Amer M, Shaashua L, Glasner A, Erez N, Agalliu D, Mayo L, Ben-Eliyahu S, Blinder P. PLoS Biol. 2019 Mar 28; [Epub ahead of print]. [link to PubMed]
Cell composition analysis of bulk genomics using single-cell data.
Frishberg A, Peshes-Yaloz N, Cohn O, Rosentul D, Steuerman Y, Valadarsky L, Yankovitz G, Mandelboim M, Iraqi FA, Amit I, Mayo L, Bacharach E, Gat-Viks I. Nat Methods. 2019 Apr;16(4):327-332. [link to PubMed]
Acute microglia ablation induces neurodegeneration in the somatosensory system.
Rubino SJ, Mayo L, Wimmer I, Siedler V, Brunner F, Hametner S, Madi A, Lanser A, Moreira T, Donnelly D, Cox L, Rezende RM, Butovsky O, Lassmann H, Weiner HL. Nat Commun. 2018 Nov 1;9(1):4578. [link to PubMed]
Dissection of influenza infection in vivo by single-cell RNA sequencing
Steuerman Y, Cohen M, Peshes-Yaloz N, Valadarsky L,Cohn O,David E, Frishberg A, Mayo L, Bacharach E, Amit I, and Gat-Viks I. Cell Syst. 2018 Jun 27;6(6):679-691 [link to PubMed]
RIPK1 mediates axonal degeneration by promoting inflammation and necroptosis in ALS.
Ito Y, Ofengeim D, Najafov A, Das S, Saberi S, Li Y, Hitomi J, Zhu H, Chen H, Mayo L, Geng J, Amin P, DeWitt JP, Mookhtiar AK, Florez M,Ouchida AT, Fan JB, Pasparakis M, Kelliher MA, Ravits J, Yuan J. Science. 2016 Aug Vol. 353, Issue 6299, pp. 603-608 [link to PubMed]
IL-10 dependent Tr1 cells attenuate astrocyte activation and ameliorate chronic CNS inflammation.
Mayo L, Pires Da Cunha A, Beynon V, Yang Z, Alvarez JI, Part A, Sobel RA, Kobzik L, Lassmann H, Quintana FJ, Weiner HL. Brain. 2016 Jul;139(7):1939-1957.
This work was highlighted by:
Type I interferons and microbial metabolites of tryptophan modulate astrocyte activity and central nervous system inflammation via the aryl hydrocarbon receptor.
Rothhammer V, Mascanfroni DI, Bunse L, Takenaka M, Kenison J, Mayo L, Chao C , Patel B, Yan R, Blain M, Alvarez JI, Kébir H,Anandasabapathy N, Izquierdo G, Jung S, Obholzer N, Pochet N, Clish CB, Prinz M, Prat A, Antel J, Quintana FJ. Nat Med. 2016 Jun;22(6):586-97. [link to PubMed]
This work was highlighted by:
Regulation of astrocyte activation by glycolipids drives chronic CNS inflammation.
Mayo L, Trauger SA, Blain M, Nadeau M, Patel B, Alvarez JI, Mascanfroni ID, Yeste A, Kivisäkk P, Kallas K, Ellezam B, Bakshi R, Prat A, Antel JP, Weiner HL, Quintana FJ. Nat Med. 2014 Oct;20(10):1147-56.
This work was highlighted by:
IL-27 acts on DCs to suppress the T cell response and autoimmunity by inducing expression of the immunoregulatory molecule CD39.
Mascanfroni ID, Yeste A, Vieira SM, Burns EJ, Patel B, Sloma I, Wu Y, Mayo L, Ben-Hamo R, Efroni S, Kuchroo VK, Robson SC, Quintana FJ. Nat Immunol. 2013 Oct;14(10):1054-63. [link to PubMed]
Impaired glutamate recycling and GluN2B-mediated neuronal calcium overload in mice lacking TGF-β1 in the CNS.
Koeglsperger T, Li S, Brenneis C, Saulnier JL, Mayo L, Carrier Y, Selkoe DJ, Weiner HL. Glia. 2013 Jun;61(6):985-1002. [link to PubMed]
CD38 deficiency in the tumor microenvironment attenuates glioma progression and modulates features of tumor-associated microglia/macrophages.
Levy A, Blacher E, Vaknine H, Lund FE, Stein R, Mayo L. Neuro Oncol. 2012 Aug;14(8):1037-49. [link to PubMed]
The innate immune system in demyelinating disease.
Mayo L, Quintana FJ, Weiner HL. Immunol Rev. 2012 Jul;248(1):170-87 [link to PubMed]
Bid regulates the immunological profile of murine microglia and macrophages.
Mayo L, Levy A, Jacob-Hirsch J, Amariglio N, Rechavi G, Stein R. Glia. 2011 Mar;59(3):397-412 [link to PubMed]
CD38 facilitates recovery from traumatic brain injury.
Levy A, Bercovich-Kinori A, Alexandrovich AG, Tsenter J, Trembovler V, Lund FE, Shohami E, Stein R, Mayo L. J Neurotrauma. 2009 Sep;26(9):1521-33 [link to PubMed]
Dual role of CD38 in microglial activation and activation-induced cell death.
Mayo L, Jacob-Hirsch J, Amariglio N, Rechavi G, Moutin MJ, Lund FE, Stein R. J Immunol. 2008 Jul 1;181(1):92-103. [link to PubMed]
Reduced folate carrier gene silencing in multiple antifolate-resistant tumor cell lines is due to a simultaneous loss of function of multiple transcription factors but not promoter methylation.
Rothem L, Stark M, Kaufman Y, Mayo L, Assaraf YG. J Biol Chem. 2004 Jan 2;279(1):374-84. [link to PubMed]
