Tom Meyer, Dor Shimon, Sawsan Youssef, Gal Yankovitz, Adi Tessler, Tom Chernobylsky, Anat Gaoni-Yogev, Rita Perelroizen, Noga Budick-Harmelin, Lawrence Steinman, Lior Mayo. PNAS. In press
Selected Publications
NAD metabolism drives astrocyte proinflammatory reprogramming in central nervous system autoimmunity
Astrocyte immunometabolic regulation of the tumour microenvironment drives glioblastoma pathogenicity.
Rita Perelroizen,Bar Philosof, Noga Budick-Harmelin, Tom Chernobylsky, Ariel Ron, Rotem Katzir,Dor Shimon, Adi Tessler, Orit Adir, Anat Gaoni-Yogev, Tom Meyer, Avivit Krivitsky, Nuphar Shidlovsky, Asaf Madi, Eytan Ruppin, Lior Mayo.Brain. Ahead of print
Control of tumor-associated macrophages and T cells in glioblastoma via AHR and CD39.
Takenaka MC, Gabriely G, Rothhammer V, Mascanfroni ID, Wheeler MA, Chao CC, Gutiérrez-Vázquez C, Kenison J, Tjon EC, Barroso A, Vandeventer T, de Lima KA, Rothweiler S, Mayo L, Ghannam S, Zandee S, Healy L, Sherr D, Farez MF, Pratt A, Antel J, Reardon DA, Zhang H, Robson SC, Getz G, Weiner HL, Quintana FJ.Nat Neurosci. 2019 May;22(5):729-740. [link to PubMed]
Prophylactic TLR9 stimulation reduces brain metastasis through microglia activation.
Benbenishty A, Gadrich M, Cottarelli A, Lubart A, Kain D, Amer M, Shaashua L, Glasner A, Erez N, Agalliu D, Mayo L, Ben-Eliyahu S, Blinder P. PLoS Biol. 2019 Mar 28; [Epub ahead of print]. [link to PubMed]
Cell composition analysis of bulk genomics using single-cell data.
Frishberg A, Peshes-Yaloz N, Cohn O, Rosentul D, Steuerman Y, Valadarsky L, Yankovitz G, Mandelboim M, Iraqi FA, Amit I, Mayo L, Bacharach E, Gat-Viks I. Nat Methods. 2019 Apr;16(4):327-332. [link to PubMed]
Acute microglia ablation induces neurodegeneration in the somatosensory system.
Rubino SJ, Mayo L, Wimmer I, Siedler V, Brunner F, Hametner S, Madi A, Lanser A, Moreira T, Donnelly D, Cox L, Rezende RM, Butovsky O, Lassmann H, Weiner HL. Nat Commun. 2018 Nov 1;9(1):4578. [link to PubMed]
Dissection of influenza infection in vivo by single-cell RNA sequencing
Steuerman Y, Cohen M, Peshes-Yaloz N, Valadarsky L,Cohn O,David E, Frishberg A, Mayo L, Bacharach E, Amit I, and Gat-Viks I. Cell Syst. 2018 Jun 27;6(6):679-691 [link to PubMed]
RIPK1 mediates axonal degeneration by promoting inflammation and necroptosis in ALS.
Ito Y, Ofengeim D, Najafov A, Das S, Saberi S, Li Y, Hitomi J, Zhu H, Chen H, Mayo L, Geng J, Amin P, DeWitt JP, Mookhtiar AK, Florez M,Ouchida AT, Fan JB, Pasparakis M, Kelliher MA, Ravits J, Yuan J. Science. 2016 Aug Vol. 353, Issue 6299, pp. 603-608 [link to PubMed]
IL-10 dependent Tr1 cells attenuate astrocyte activation and ameliorate chronic CNS inflammation.
Mayo L, Pires Da Cunha A, Beynon V, Yang Z, Alvarez JI, Part A, Sobel RA, Kobzik L, Lassmann H, Quintana FJ, Weiner HL. Brain. 2016 Jul;139(7):1939-1957.
This work was highlighted by:
This work resulted in the development of Foralumab, a nasal-administrated drug for secondary progressive multiple sclerosis (SPMS), which is currently (August 2022) is already already helping SPMS patients in FDA-supervised clinical studies See recent update at Multiple Sclerosis News Today.
Type I interferons and microbial metabolites of tryptophan modulate astrocyte activity and central nervous system inflammation via the aryl hydrocarbon receptor.
Rothhammer V, Mascanfroni DI, Bunse L, Takenaka M, Kenison J, Mayo L, Chao C , Patel B, Yan R, Blain M, Alvarez JI, Kébir H,Anandasabapathy N, Izquierdo G, Jung S, Obholzer N, Pochet N, Clish CB, Prinz M, Prat A, Antel J, Quintana FJ. Nat Med. 2016 Jun;22(6):586-97. [link to PubMed]
This work was highlighted by:
Regulation of astrocyte activation by glycolipids drives chronic CNS inflammation.
Mayo L, Trauger SA, Blain M, Nadeau M, Patel B, Alvarez JI, Mascanfroni ID, Yeste A, Kivisäkk P, Kallas K, Ellezam B, Bakshi R, Prat A, Antel JP, Weiner HL, Quintana FJ. Nat Med. 2014 Oct;20(10):1147-56.
This work was highlighted by:
IL-27 acts on DCs to suppress the T cell response and autoimmunity by inducing expression of the immunoregulatory molecule CD39.
Mascanfroni ID, Yeste A, Vieira SM, Burns EJ, Patel B, Sloma I, Wu Y, Mayo L, Ben-Hamo R, Efroni S, Kuchroo VK, Robson SC, Quintana FJ. Nat Immunol. 2013 Oct;14(10):1054-63. [link to PubMed]
